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King Henry VIII's sergeant-surgeon, Thomas Vicary, was appointed as the hospital's first superintendent.

The Priory's principal church, St Bartholomew-the-Great, was reconfigured after the dissolution of the monasteries, losing the western third of its nave.

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Part of the site is now occupied by Barts and The London School of Medicine and Dentistry.

From its inception, the Priory of St Bartholomew treated the sick.

A chapel and hermitage were constructed, renamed New Church Haw; but in 1371, this land was granted for the foundation of the Charterhouse, originally a Carthusian monastery.

Nearby and to the north of this demesne, the Knights Hospitaller established a Commandery at Clerkenwell, dedicated to St John in the mid-12th century.

On 29 May, the remaining twenty monks and eighteen lay brothers were forced to swear the oath of allegiance to King Henry VIII; the ten who refused were taken to Newgate Prison and left to starve.

With the monks expelled, Charterhouse was requisitioned and remained as a private dwelling until its reestablishment by Thomas Sutton in 1611 as a charitable foundation; it was the basis of the school named Charterhouse and almshouses known as Sutton's Hospital in Charterhouse on its former site. Until 1899 Charterhouse was extra-parochial; Some of the property was damaged during The Blitz, but it remains largely intact.

The area also contains London's oldest surviving church, St Bartholomew-the-Great, founded in 1123 AD.

Smithfield has borne witness to many executions of heretics and political rebels over the centuries, including Scottish patriot Sir William Wallace, and Wat Tyler, leader of the Peasants' Revolt, among many other religious reformers and dissenters.

A trading event for cloth and other goods as well as being a pleasure forum, the four-day festival drew crowds from all strata of English society.

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