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To our knowledge, this is the first report to demonstrate the long-term therapeutic activity of combination S-1 and cisplatin adjuvant chemotherapy against invasive signet-ring cell carcinoma of the urinary bladder.Adenocarcinoma of the urinary bladder accounts for 0.5%–2% of all bladder cancers with signet-ring cell carcinoma being an aggressive phenotype characterized by signet-ring cells containing intracellular mucin-filled vacuole, which displaces the hyperchromatic nucleus to one side of the cell [1].

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Cystoscopy revealed widely prevalent nonpapillary raised lesions and edematous mucosa on the posterior wall of the bladder.

Pelvic computed tomography (CT) scan demonstrated marked diffuse bladder wall thickening without swelling of the pelvic lymph nodes.

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Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya 467-8601, Japan Received 25 March 2013; Accepted 13 April 2013Academic Editors: A. We report a case of signet-ring cell carcinoma of the urinary bladder with a long-term survival of 90 months owing to radical cystectomy and combination adjuvant chemotherapy with S-1 and cisplatin.

He is still alive 90 months with no evidence of tumor recurrence or metastasis.

Figure 1: (a) CT shows diffuse tumor of the urinary bladder wall.

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It is a response to the mounting interest in these increasingly inter-related fields, and the absence of any single group addressing them in a comprehensive, multidisciplinary fashion.

Primary signet-ring cell carcinoma of the urinary bladder (SRCCU) is a rare neoplasm that has a very high mortality rate and can be primary (arising from the bladder wall or urachus remnants) or metastatic (tumors originating in the stomach, colon, or breast) [2].

It accounts for approximately 0.24% of all bladder malignancies.

A 53-year-old Japanese man with a history of pain on urination and hematuria for several months was referred to our hospital.

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